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N2404

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Neurophysin I from bovine pituitary

CAS Number:63231-59-4
MDL number:MFCD00131715

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Description

Biochem/physiol ActionsMutations leading to disruptions of the structure and/or conformation of neurophysins are implicated in the pathophysiology of central diabetes insipidus (CDI).
Other NotesProtein found in vasopressin- and oxytocin-containing neurons in the hypothalamus that is associated with the transport of these hormones to the posterior pituitary.

Properties

mol wtmol wt ~10 kDa
storage temp.2-8°C

Safety

Personal Protective EquipmentEyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany3

References

referencede Bree, F.M. and Burbach, J., Structure-function relationships of the vasopressin prohormone domains. Cell. Mol. Neurobiol. 18, 173, (1998) Abstract
 Kazmierkiewicz, R., et al., Elucidation of neurophysin/bioligand interactions from molecular modeling. Acta Biochim. Pol. 44, 453-466, (1997) Abstract
 Legros, J.J., and Geenen, V., Neurophysins in central diabetes insipidus. Horm. Res. 45, 182-186, (1996) Abstract
 Audhya,TK., and Walter, R., Highly purified neurophysin proteins: method of isolation based on their acidic properties. Arch. Biochem. Biophys. 180, 130-139, (1977) Abstract
 Kim, J.K. and Schrier, R.W., Vasopressin processing defects in the Brattleboro rat: implications for hereditary central diabetes insipidus in humans?. Proc. Assoc. Am. Physicians 110, 380-386, (1998) Abstract